Lauren Graham and Andrea Roth — separated at birth?

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Chris, Edinburgh, Scotland Sun, Dec 14, 2008 at 12:53 PM EST

Zooey Deschanel and Kate Capshaw. They both look alike. Add the singer Katy Perry and you have triplets.

Em Thu, Jan 31, 2008 at 11:52 PM EST

Jason Dohring and Ed Norton

Tue, Jan 29, 2008 at 10:56 PM EST

great show love you

Tue, Jan 29, 2008 at 10:56 PM EST

great show love you

BC Tue, Jan 22, 2008 at 01:08 PM EST

Cillian Murphy and James Spader

N Mon, Jan 21, 2008 at 02:02 PM EST

In regards to the Lauren Graham and Jenna Elfman combo - some trivia: they played friends and roommates in the old show "Townies"

BarleyWine Mon, Jan 21, 2008 at 10:54 AM EST

Kelly Ripa and Kristin Chenoweth

Cristina Sun, Jan 20, 2008 at 06:33 PM EST

Liz Phair (if she acted) and Meg Ryan - they look exactly alike.

cb Sun, Jan 20, 2008 at 05:28 PM EST

Blake Lively from Gossip Girl and Kate Hudson. They look exactly alike! :-)

davie Sun, Jan 20, 2008 at 09:51 AM EST

andrea roth and charlize theron, or andrea roth and heather locklear and if you watch rescue me, you'll see why maybe even andrea rotha and angelina jolie - they even have the same voice.

davie Sun, Jan 20, 2008 at 09:48 AM EST

andrea roth and charlize theron, or andrea roth and heather locklear and if you watch rescue me, you'll see why maybe even andrea rotha and angelina jolie - they even have the same voice.

davie Sun, Jan 20, 2008 at 09:47 AM EST

andrea roth and charlize theron, or andrea roth and heather locklear

Silv Sat, Jan 19, 2008 at 08:26 PM EST

Agree with Helen Hunt/Leelee Sobieski combo - always thought their resemblance was uncanny. Also like what was said about Josh Hartnett & Tommy Lee Jones. How about Eddie Murphy/Chris Tucker? Mary Louise Parker & Parker Posey?

Owen Sat, Jan 19, 2008 at 06:53 PM EST

Tina Fey and Ingrid Michaelson could definitely play sisters in a movie. Or a TV show. Or a book with lots of pictures.

To Brainiac Sat, Jan 19, 2008 at 05:12 PM EST

How could you insult George Clooney by saying that Taylor Hicks could play his brother!!!! Poor George!

And though he is not an actor (and I hope he never tries), but Spencer from the Hills could easily pass for any of the Gremlins! (thanks EW TV WATCH!)

Lee Sat, Jan 19, 2008 at 04:09 PM EST

Parker Posey, Elizabeth Banks, and Chelsea Handler.

Martin Sat, Jan 19, 2008 at 02:14 PM EST

Cameron Diaz and Malin Akerman (The Comeback, 27 Dresses) could play sisters.
http://moviemartin.blogspot.com (Did anyone catch that thing at the end of Cloverfield?)

Brainiac Sat, Jan 19, 2008 at 12:33 PM EST

I sort of think that if Taylor Hicks could act, he might be a suitable younger brother for George Clooney.

The guy who played Ryan on the OC (sorry, the name is on the tip of my tongue) and Russel Crowe could also pull off some sort of blood relation - when Russel Crowe is clean-shaven.

monica Sat, Jan 19, 2008 at 11:27 AM EST

i nominate Isla Fisher and Amy Adams, who I used to confuse, & Anna Faris with Amy Poehler. Katherine heigl's beautiful, but she doesn't look anything like charlize theron. the kim kardishian-nicole scherzinger & k.d. lang-toby maguire comparisons were so mean. lol but i totally agree with the Bruce Campbell-Xander relation.

Welles Sat, Jan 19, 2008 at 09:14 AM EST

K.D. Lang & Toby Maguire

Jo Sat, Jan 19, 2008 at 05:41 AM EST

I always wanted to see Bruce Campbell show up on Buffy the Vampire Slayer as Xander's Uncle Rory. Of course, Xander's actor (Nicholas Brendon)already has an identical twin brother, so that's just more opportunity to expand the family, right?

snee Sat, Jan 19, 2008 at 02:03 AM EST

rachel mcadams and jessica paré.

Sat, Jan 19, 2008 at 01:38 AM EST

The brothers on suite life of zach and cody look EXACTLY alike. that was a great job casting

Sat, Jan 19, 2008 at 01:38 AM EST

The brothers on suite life of zach and cody look EXACTLY alike. that was a great jod casting

Sat, Jan 19, 2008 at 01:35 AM EST

Timothy Olyphant could play Josh Duhamel's evil twin

Rob Grizzly Fri, Jan 18, 2008 at 11:55 PM EST

Joaquin Phoenix and Johnathan Ryes-Meyers

Helen Hunt and Leelee Sobieski

Raven_Moon Fri, Jan 18, 2008 at 11:18 PM EST

I'm not saying they look the same, necessarily, but I think Angelina Jolie & Keira Knightly could pull off a believable family tie. Also, Charlize Theron looks like Katherine Heigl's older sister and Angie Harmon & Sandra Bullock could belong to the same family, as well.

hadn't thought of it Fri, Jan 18, 2008 at 11:09 PM EST

but I agree with cw... Josh Charles and James McAvoy

cw Fri, Jan 18, 2008 at 09:39 PM EST

James McAvoy and Josh Charles

Robbie Fri, Jan 18, 2008 at 06:49 PM EST

I always thought Jenna Elfman could play a perfect sister to Lauren Graham.

Adrian Fri, Jan 18, 2008 at 06:23 PM EST

I think "Gossip Girl"'s Blake Lively bears a really uncanny resemblance to Ellen Pompeo, who in turn is reminiscent of Renee Zellweger.

sarah Fri, Jan 18, 2008 at 06:13 PM EST

That chick on the right looks plastic and gross and more like Meg Ryan than anything else. I think Lauren Graham is gorge but not in the picture you have posted.

People that I would like to see play siblings because they look so sim: Obvs Kurt Russell, Kris Kristoferson and Patrick Swayze. TRIPLETS!

Dave Fri, Jan 18, 2008 at 06:06 PM EST

I don't know if Colbie Caillat with the hit song "Bubbly" can act, but she looks like she could be Jen Aniston's baby sis.

tia Fri, Jan 18, 2008 at 06:03 PM EST

Tyler Labine (Reaper) and Jack Black should play brothers. And for sisters, Ellen Pompeo and Renee Zellweger or Angie Harmon and Sandra Bullock.

gigi Fri, Jan 18, 2008 at 05:53 PM EST

Monica Potter is Julia Roberts younger sister. And MoroccoMole, you are DEAD ON!

doneanddone Fri, Jan 18, 2008 at 05:53 PM EST

it's already been done...but for the longest time i thought kyra sedgwick and julia roberts were actually sisters. (something to talk about)

Leigh Fri, Jan 18, 2008 at 05:29 PM EST

I always thought Lauren Graham and Jenna Elfman could play sisters. And I definitely agree that Chad Smith (Red Hot Chili Pepper's drummer) and Will Ferrell could pass as brothers. Good call!

MoroccoMole Fri, Jan 18, 2008 at 05:20 PM EST

John Cameron Mitchell reprises his role as Hedwig, with Rachel Griffiths as her identical twin sister.

tuppy Fri, Jan 18, 2008 at 05:14 PM EST

for years — okay: like, a week — I thought pamela adlon (the wife on "lucky louie," which I hated with a fiery passion for replacing "the comeback") and constance zimmer (dana gordon on "entourage") were the same person. they could def play sisters, and rashida jones would play their half-black half-sister...and leah remini would be their funny blue-collar cousin...okay, that's enough.

Sara Fri, Jan 18, 2008 at 04:57 PM EST

So neither of them are actresses, but I totally can't tell the difference between Kim Kardashian and Nicole Sherzinger. They could definitely play sisters.

Jeanette Fri, Jan 18, 2008 at 04:43 PM EST

OK, I know he's not an actor, but the drummer in the Red Hot Chili Peppers should play Will Farrell's brother in something.

ceci Fri, Jan 18, 2008 at 04:36 PM EST

Lelee Sobieski and Helen Hunt. Maybe daughter and mother?

arahsae Fri, Jan 18, 2008 at 04:30 PM EST

Charlize Theron and Katherine Heigl...

mscisluv Fri, Jan 18, 2008 at 04:28 PM EST

I really don't see the resemblance. If anything, I agree that Andrea Roth looks like Heather Locklear.

Ibis1996 Fri, Jan 18, 2008 at 04:20 PM EST

Looking at that photo of Andrea Roth makes me think she could perfectly play the sister of Heather Locklear.

Beetle Fri, Jan 18, 2008 at 03:58 PM EST

Tom Cruise and Ben Stiller should -- oh, wait.

Anyway... It's not siblings, but Tommy Lee Jones and Josh Hartnett would work perfectly as father and son (or Hartnett playing a young Jones).

Jane Fri, Jan 18, 2008 at 03:57 PM EST

I've always thought that James McAvoy (http://imdb.com/name/nm0564215/) and Gregory Smith (http://imdb.com/name/nm0564215/) looked freakishly similar (I even operated under the assumption they were the same person for awhile). I could totally see them playing siblings in a film.

Eve Fri, Jan 18, 2008 at 03:41 PM EST

Johnny Depp and Daniel-Day Lewis would be perfectly cast as brothers!!